Uses

It is used in the treatment of type II diabetes. As of 2007^[update], it is one of only two oral anti-diabetics in the World Health Organization Model List of Essential Medicines (the other being metformin).^[1] As of 2003, in the United States, it was the most popular sulfonyurea.^[2]

Additionally, recent research shows that glyburide improves outcome in animal stroke models by preventing brain swelling. A retrospective study showed that in type 2 diabetic patients already taking glyburide there was improved NIH stroke scale scores on discharge compared to diabetic patients not taking glyburide.

Glibenclamide
Systematic (IUPAC) name
5-chloro-N-(4-[N-(cyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-methoxybenzamide
Identifiers
CAS number	10238-21-8
ATC code	A10BB01
PubChem	3488
DrugBank	APRD00233
Chemical data
Formula	C23H28ClN3O5S
Mol. mass	494.004 g/mol
Pharmacokinetic data
Bioavailability	?
Protein binding	Extensive
Metabolism	Hepatic hydroxylation (CYP2C9-mediated)
Half life	10 hours
Excretion	Renal and biliary
Therapeutic considerations
Licence data	US FDA:link
Pregnancy cat.	C(AU) B(US)
Legal status	POM(UK) ℞-only(US)
Routes	Oral